妊娠高血压疾病患者血液流变学和血液动力学变化的临床意义

Changes and significances of blood dynamics parameters and hemorrheology in the pregnancy induced hypertension

目的:探讨妊娠高血压疾病患者血液流变学参数和血液动力学的变化特点。方法:用普利生LYB-N6A型全自动血粘度仪和无创伤心血管参数测量仪对120例妊娠高血压疾病患者、150例正常妊娠妇女及100例正常对照者进行血流变学和血液动力学指标检测。结果:3组间有不同的血液流变学和血液动力学。正常妊娠组和正常对照组间的全血粘度、血浆粘度、平均动脉压(MAP)、心输出量(CO)、心脏指数(CI)、心搏量(SV)、心搏指数(SI)及血管顺应性(AC)之间的差异无统计学意义(P>0.05),而妊娠高血压组的全血粘度、血浆粘度、平均动脉压明显高于正常对照组和正常妊娠组(P<0.05),心输出量、心脏指数、心搏量、心搏指数及血管顺应性则明显低于正常对照组和正常妊娠组(P<0.05)。结论:监测孕妇血液流变学和血液动力学多项指标,有助于预测妊娠高血征疾病的发生、发展和严重程度,对妊娠高血压的治疗有一定的临床指导意义。

Objective： To explore changes of blood dynamics parameters and hemorrheology in normal control, normal pregnancy and pregnancy induced hypertension （PIH） . Methods： The subjects were divided into three groups, including normal control （100 persons）, normal pregnancy group （150） and PIH group （120）. Automatic machine of blood viscosity and non-invasive cardiovascular parameters surveyor were used to measure blood dynamics parameters and hemorrheology of different groups. Results： Discrepant blood dynamics parameters and hemorrheology were found among three groups. The whole blood viscosity, plasma viscosity, average arterial pressure （MAP） , cardiac output （CO） , cardiac index （CI） , stroke volumes （SV） , stroke index （SI） and anglo-compliance （AC） between normal control and normal pregnancy had no statistical difference （ P 〉 0. 05 ）. But whole blood viscosity, plasma viscosity, MAP in PIH were obviously higher than those in normal control group and normal pregnancy （ P 〈 0. 05 ）, on the contrary CO, CI, SV, SI and AC were less than those in normal control group and normal pregnancy significantly （ P 〈 0. 05 ） . Conclusion： Monitoring blood dynamics parameters and hemorrheology is conductive to predict outset, development and severity of PIH. Furthermore, it could helpful for treatment on PIH.