胃癌组织中环氧合酶-2的表达及其意义

Expression of COX-2 in human gastric carcinoma tissues and the clinical significances

目的研究胃癌组织中环氧合酶-2(COX-2)的表达,探讨其与临床病理特征的关系。方法采用免疫组化S-P法检测COX-2在85例胃癌组织和20例正常胃组织中的表达。结果COX-2在胃癌组织中的阳性表达率为77.6%,在正常胃粘膜中未见表达,差异有统计学意义(P<0.05);COX-2在胃癌组织中的表达与临床分期、淋巴结转移有关,差异有统计学意义(P<0.05);COX-2在胃癌组织中的表达与胃癌组织学分型、肿瘤大小、患者性别及年龄均无明显关系。结论COX-2在胃癌组织中高表达,COX-2高表达与胃癌的临床分期及淋巴转移呈正相关,与胃癌的发生发展及淋巴转移有密切关系,胃癌组织中COX-2检测具有重要意义。

Objective To investigate the expression of COX-2 in gas-tric carcinoma tissues, and study its correlation with clinic pathologic characteristies.Methods COX-2 expression were examined by immunohist-ochemical S-P in 85 specimens of gastric carcinoma tissues and 20 specimens of normal gastric tissues. Results The positive rate of COX-2 expression in gastric carcinoma was77.6 %, and there was no expression in normal gastric tissues. The expression of COX-2 has significant difference be-tween gastric carcinoma and normal gastric tissues（ P 〈 0.05） .The expression of COX-2 was positively correlated with clinical stage （ P 〈 0.05）, and lymph node matastasis （P 〈 0.05）.but was negatively gastric with histological types,size of tumor,and sex and age of patient. Conclusion In gastric carcinoma, the expression rate COX-2 was high, COX-2 expression was positively correlated with clinical stage, and lymph node metastasis; COX-2 play an important role in the carcinogenesis and metastasis of gastric carcinoma , It is that COX-2 in gastric cancer tissues will be of significance.