病毒性肝炎患者血清中肝纤维化标志物的联合测定

Determine markers of liver fibrosis in viral hepatitis patients

目的联合测定病毒性肝炎患者血清中肝纤维化标志物以全面分析肝纤维化情况。方法放射免疫法检测血清肝纤维化标志物HA、PCⅢ、LN。结果病毒性肝炎患者血清HA含量从轻度慢肝到肝硬化各组变化显著,与正常对照及前一组比较差异均有显著性(P<0.01),尤其在肝硬化时升高明显。但血清PCⅢ、LN含量在各检测组和对照组间差异显著(P<0.01),中度与轻度慢肝组间差异显著(P<0.01),而重度与中度、肝硬化与重度慢肝组间差异均无显著性(P>0.05)。肝硬化组血清LN平均水平明显高于慢性肝炎组水平,但差异无统计学意义(P>0.05)。肝硬化组血清PCⅢ平均水平明显低于重度慢肝组(P<0.05)。结论慢性病毒性肝炎病人血清HA、PCIII、LN水平能综合反映肝纤维化的程度。

Objective Determine viral hepatitis in patients with liver fibrosis markers of liver fibrosis in a comprehensive analysis of the situation. Methods RIA detect markers of liver fibrosis serum HA,PC Ⅲ, LN. Results Patients with hepatitis serum HA content from mild to slow liver cirrhosis of the group changes significantly, and a control group and the former were significantly different （P 〈 0.01）, especially inereased significantly in cirrhosis. Serum PC Ⅲ, LN content in the test group and control group significantly different （ P 〈 0.01） ,Slow and mild to moderate liver significant differences between groups （ P 〈 0.01 ）,but severe and moderate, severe cirrhosis and liver slow group there was no significant difference（ P 〉 0.05）. Cin＇hosis of serum LN significantly higher than the average level of chronic hepatitis,but there was no significant difference（ P 〉 0.05）.Serum PC Ⅲ cinrhesis group was significantly lower than the average level of severe liver slow Group（ P 〈 0.05）. Conclusion HA,PCⅢ,LN in chrnic viral hepatitis patients can reflect the level to the extent of liver fibrosis.