影响喉癌患者预后的Cox回归分析

Multivariate Cox analysis of prognostic factors affecting laryngeal cancer patients

目的:探讨影响喉癌患者生存率的相关因素。方法:回顾性分析77例喉癌患者的临床资料,包括年龄、性别、吸烟、族别、肿瘤部位、病理学分级、T分期、N分期、临床分期和治疗方式。应用Kaplan-Meier进行生存分析,组间比较用Log rank检验,多因素分析采用Cox比例风险模型。结果:本组患者总的1年、3年、5年生存率分别为98.7%、73.4%、54.1%。单因素分析提示肿瘤部位、病理学分级、T分期、N分期、临床分期、治疗方式对患者预后的影响均有统计学意义(P<0.05);多因素分析发现肿瘤部位(P<0.05)、病理学分级(P<0.05)、临床分期(P<0.05)、治疗方式(P<0.01)对预后的影响有统计学意义。结论:影响喉癌患者预后的独立因素是肿瘤部位、病理学分级、临床分期和治疗方式。

Objective：To investigate the factors affecting the survival rate of laryngeal carcinoma.Methods：Seventy-seven cases were analyzed retrospectively,including sex,age,smoking,race,primary site,pathological grade,T-stage,N-stage,clinical stage,treatment methods.Survival analysis was performed by Kaplan-Meier method,comparison between groups was performed using log rank test,multivariate analysis was carried out using Cox proportional hazard model.Results：Overall 1,3 and 5-year survival rates were 98.7%,73.4% and 54.1% respectively.Univariate analysis showed that primary site,pathological grade,T-stage,N-stage,clinical stage and treatment methods were proven to significant（P〈0.05）.Multivariate analysis showed the prognosis statistically correlated with primary site（P〈0.05）,pathological grade（P〈0.05）,clinical stage（P〈0.05） and treatment methods（P〈0.01）.Conclusion：The independent factors affecting the prognosis of the patients with laryngeal carcinoma are primary site,pathological grade,clinical stage and treatment methods.