犬24h房颤心房形态及心功能变化的研究

Evaluation atrial size and left ventricular function in a canine atrial fibrillation model by pacing 24 hours right atrium

目的:探讨心房颤动(AF)持续24 h对犬左、右房大小及心功能的影响。方法:全麻状态下,快速起搏(600次/min)犬右心房建立房颤模型,观察AF后0、4、8、12、24 h左、右心房横径、心室射血分数(EF)的变化。结果:随着AF的持续,左、右房横径均逐渐增大,但增大幅度与0 h比较差异无统计学意义(P>0.05)。房颤12 h心室射血分数降低7.48%,24 h降低8.81%,与0 h比较差异有统计学意义(P<0.05)。结论:快速起搏犬右心房所致AF持续24 h后,心室射血分数从12 h开始降低,与心房肌降低泵血功能,减少向心室排血有关,是心房增大的原因之一。心房结构随着AF进程有逐渐增大的趋势,可能参与了阵发性房颤的结构重构。

Objectives： To observe the changes of left, right atrium size and heart function in canine atrial fibrillation model by pacing 24 hours right atrium. Methods： Establishing atrial fibrillation model induced by a rapid right atrial pacing （600 beats/min）, left , right atrium size and left ventricular ejection fraction were measured after AF 0, 4, 8, 12, 24 hours by Echocardiogram. Results： Left, right atrium transverse diameter gradually increased, but have no significant difference （P 〉0.05）. Left ventricular function significantly decreased 7.48% on AF 12 h and 8.81%on AF 24h compared with that on AF 0 h （P d0.05）. Conclusions： 24 hours AF can cause atriums enlargement trendency and left ventricular ejection function impairment which probably are one of the mechanisms of atrial structure remodeling in paroxysmal atrial fibrillation.