新疆哈萨克族、汉族食管癌组织中Fas、Bax的表达及其临床意义

Study on the clinical significance and the expression of Fas and Bax in esophageal carcinoma tissue in Kazak and Han nationality in Xinjiang

目的:探讨凋亡相关基因Fas、Bax在新疆哈萨克族(哈族)、汉族食管鳞状上皮细胞癌(鳞癌)组织中的表达及其临床意义。方法:应用免疫组化LSAB法及原位凋亡Tunel试剂盒检测86例(哈族53例,汉族33例)食管鳞癌和10例癌旁远端正常食管组织中Fas、Bax蛋白的表达及鳞癌细胞的凋亡。结果:(1)Fas、Bax蛋白在86例食管鳞癌中的阳性表达率分别为89.5%(77/86)、41.9%(36/86),而在远端正常食管组织中的阳性表达率分别为70.0%(7/10)、50.0%(5/10)。(2)哈族与汉族食管鳞癌组织中的Fas、Bax表达及细胞凋亡检测差异无统计学意义(P>0.05)。(3)Fas、Bax在不同分化程度的食管鳞癌组织中的表达差异有统计学意义(P<0.05)。(4)Fas、Bax在淋巴结转移和未转移病例间的表达差异无统计学意义(P>0.05)。结论:Fas、Bax的表达与食管鳞癌的分化有关,Fas、Bax的表达可用于判断食管癌的恶性程度以及推断临床预后。

Objective： To study on the expression and the clinical significance of Fas and Bax in esophageal squamous carcinoma tissues in Kazak and Han nationnality in Xinjiang. Method： Eighty six tissues with esophageal squamous-eell carcinoma and 10 normal tumor-adjacent tissues were examined for Fas and Bax by immunohistoehemisry. Result： （1）The positive frequency of expression of Fas, Bax in 86 tissues with esophageal squamous-eell carcinoma were 89.5%（77/86）, 41.9% （36/86）respectively. And the expression of those in normal tumor-adjacent tissues were 70.0%（7/10）, 50.0%（5/10）. （2） No statistic significance of expression of Fas, Bax was found among different ethnic patients in Xinjiang （P 〉0.05）. （3） There were statistic significance among raring degrees of differentiation （P 〈0.05）. （4） There were no statistic significance between LMN and non-LMN （P 〉0.05）. Conclusion： （1） It suggested that the expressions of Fas, Bax are correlated with the degree of differentiation of esophageal squamous-eell carcinoma. （2） The expression of Fas, Bax could be used to assessing the degree of malignancy and predicting the clinical prognosis.