摘要
目的:研究芹菜籽油(CSO)抗D-半乳糖致衰老模型动物的作用。方法:分别对小鼠和大鼠皮下注射D-半乳糖复制衰老模型,同时灌胃给予CSO。6周后,通过跳台法和电生理方法观察CSO对衰老模型动物学习记忆的改善,同时比较衰老小鼠脑组织内丙二醛(MDA)含量及单胺氧化酶B(MAO-B)、超氧化物歧化酶(SOD)活性的差异。结果:CSO对衰老动物的学习记忆障碍有显著的改善作用;能显著降低衰老小鼠脑组织内MDA的含量和MAO-B的活性,增加SOD的活性。
OBJECTIVE： To observe the antiaging effect of celery seed oil （CSO） on aging mice and rats induced by D- galactose. METHODS： Aging models were established with D - galactose hypo. At the same time, the model animals were intragastrically given CSO. After 6 weeks, the effects of CSO on learning and memory were evaluated by step down test and electrophysiological test. And the MDA content, MAO- B and SOD activity in brains of aging mice were measured. RE- SULTS： CSO can markedly improve the learning and memory of aging mice and rats, reduce the content of MDA and activity of MAO-B, and increase SOD activity. CONCLUSION： CSO has good antiaging effect.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第24期1855-1857,共3页
China Pharmacy
关键词
学习记忆
衰老模型
芹菜籽油
Learning and memory
Aging models
Celery seed oil
