正交试验优选复方水杨酸氯霉素凝胶基质

Optimization of Basic Formula of Compound Salicylic Acid and Chloramphenicol Gel with Orthogonal Test

目的:优选复方水杨酸氯霉素凝胶基质的最佳配比。方法:以羧甲基纤维素钠、甘油、乙醇用量为考察对象,以综合评分为指标,采用L9(33)正交试验法优选基质处方,高效液相色谱法测定凝胶中水杨酸和氯霉素的含量。结果:处方中基质的最佳配比为羧甲基纤维素钠3g、甘油10g、乙醇35mL。水杨酸和氯霉素的平均加样回收率分别为99.1%和101.6%,RSD分别为0.8%和1.3%。结论:本法优选出的基质稳定,可为工业化生产提供理论依据。

OBJECTIVE： To optimize the basic formula of Compound Salicylic Acid and Chloramphenicol Gel with orthogonal design test.METHODS： The closage of CMC-Na,glycerin and ethanol were taken as the review obiect with the oligation grade as the evaluation index to conduct L9（3^3） orthogonal test and the contents of salicyclic acid and the chloramphenicol were determined by HPLC. RESULTS： The optimized basic formula was as follows： sodium carboxymethylcellulose 3 g, glycerine 10 g, and alcohol 35 mL.The average recovery of Salicylic Acid and Chloramphenicol were 99.1% and 101.6%, the RSD were 0.8% and 1.3% . CONCLUSION： The basic formula optimized with orthogonal test is proved to be stable and serve as theoretic basis for the industrialized production of this preparation.