正交试验优选愈肝宁贴剂制备工艺

Optimization of the Preparation Technology of Yuganning Patch by Orthogonal Experiment

目的:优选愈肝宁贴剂的制备工艺。方法:以用膏量、固化时间、干燥温度、干燥时间为考察因素,以初黏力、剥离强度和皮肤残留现象为指标,用正交试验法优选出最佳制备工艺。结果:以用膏量(7.6±0.1)g·100cm-2、固化时间24h、干燥温度60℃、干燥时间3.5h为最佳制备工艺,并符合质量控制方法。结论:优选的最佳工艺方案可行,所制备的愈肝宁贴剂质量稳定。

OBJECTIVE： To optimizate the preparation process of Yuganning patch. METHODS： The preparation process of Yuganning patch was optimzied by orthogonal experiment with content of ointment, setting time, drying temperature and drying time as factors and the initial strength, peeling strength and degurnming phenomenon as indexes. RESULTS： The optimum preparaition conditions were as follows： the content of ointment was （7.6±0.1）g·100cm^-2; the setting time was 24 h; the drying temperature was 60℃ and drying time was 3.5 h. And this optimized process met quality control method. CONCLUSION： The optimized preparation process is feasible and the quality of the Yuganning patch is stable.