灯盏花素注射液治疗偏头痛的临床疗效观察

Clinical Observation on Therapeutic Effect of Breviscapine Injection on Migraine

目的:观察灯盏花素注射液治疗偏头痛的临床疗效。方法:将81例偏头痛患者随机分为2组:治疗组42例,给予灯盏花素注射液20mL加入5%葡萄糖注射液300mL中静脉滴注,每天1次;对照组39例,给予盐酸氟桂利嗪胶囊10mg,每晚口服1次。14d为1个疗程,每疗程后休息15d继续治疗,共2个疗程,连续观察6个月以上。比较2组临床疗效,并观察2组治疗前、后血液流变学指标的变化。结果:治疗组疗效显著优于对照组(P<0.05);治疗后2组血液流变学指标变化比较有显著性(P<0.01或P<0.05)。结论:灯盏花素注射液治疗偏头痛疗效确切,且能够明显改善血液流变学指标。

OBJECTIVE：To observe the therapeutic effect of Breviscapine injection in treating migraine. METHODS： 81 patients with migraine were randomly divided into two groups： 42 in treatment group were treated with Breviscapine injection 20 mL added to 5% Glucose injection 300 mL iv gtt q. d, and 39 in control group with Flunarizine 10 mg po quaque nocte. The treatment lasted for 2 courses （1 course of treatment lasted 14 days） with an interval of 15 days between the two courses. The patients were followed for more than 6 months. The curative effects between the 2 groups were compared, and the variations in hemorheological indexes of the 2 groups before and after treatment were observed. RESULTS： The efficacy in the treatment was signficantly higher than in the control gorup（P〈0.05）, and there were significant differences in the indexes of hemorheology between the two groups after treatment （P 〈 0.01, P 〈 0.05）. CONCLUSION： Breviscapine injection has a definite effect on migraine, and it can also significantly improve the hemorheological indexes.