免费投药对精神分裂症疗效的一年随访研究

Efficacy of free distributing antipsychotics to the schizophrenics:one year follow-up study

目的评估免费投放抗精神病药对精神分裂症患者的疗效。方法对100例非急性期精神分裂症患者配对后按随机数字表随机分为2组,免费投放组48例和对照组52例。免费投放组由医生定时上门免费发药并巡诊,对照组自行选择普通门诊治疗,随访1年。采用简明精神病评定量表(BPRS)和社会功能缺陷筛选量表(SDSS)评估,同时监测复发、再住院、就业及服药依从情况。结果随访结束时免费投放组BPRS,SDSS评分,复发率、再住院率、就业率均显著优于对照组(P<0.05),而且服药依从性更好(P<0.01)。结论免费投放抗精神病药对精神分裂症患者的疗效优于普通门诊,能减少复发,提高患者的依从性,改善患者的社会功能。

Objective： To evaluate the efficacy of free distributing antipsychotics to the schizophrenics. Methods： One hundred schizophrenics were randomly divided into two groups, 48 in study group and 52 in control group. The free distributed group was treated at home, followed up once a week at least. Patients in control group were followed up by the general out - patient treatment. All were followed up 1 year and evaluated with the Brief Psychiatric Rating Scale（ BPRS）, Social Disability Screening Schedule（ SDSS）, and then assess relapse rate, re - hospitalization rate, reemployment rate, drug - taken compliance. Results： Compared with patients in control group, the scores of BPRS, SDSS and the relapse rate, re - hospitalization rate, reemployment rate were significantly superior in patients of study group at the end of the follow - up （ P 〈 0. 05）. Patients in study group had better drug -taken compliance than those in control group （P 〈 0.01 ）. Conclusion： The efficacy of free distribution is superior to the general out - patient treatment. The free distribution can also lower the relapse rate, improve compliance and social functions in schizophrenic.