葡萄糖转运蛋白-1在肺癌组织中的表达及临床意义

The Expression and Clinical Value of Glucotransporter-1 in Different Stages of Development of Pulmonary Carcinoma

目的:探讨葡萄糖转运蛋白-1(GLUT-1)的表达与肺癌发生、发展的关系。方法:选择60例肺癌手术切除标本及气管镜活检标本(均经病理证实),采用免疫组化SP法检测GLUT-1在以上组织中的表达,并用卡方检验和确切概率法检验对结果进行统计分析。结果:GLUT-1在肺癌组织、癌旁不典型增生组织及正常肺组织中的阳性表达率,肺癌表面组织及深部组织中的表达率,临床病理分型的表达率,以及有无淋巴结转移表达率之间差异有统计学意义(P<0.05)。结论:GLUT-1在肺癌的发生、发展中具有重要作用,有可能成为临床肺癌诊断和判断预后的一个重要指标。

Objective：To study the interrealshionship of the expression of glucotransporter-1 （GLUT-1） in different stages of development of pulmonary carcinoma. Methods：Samples were obtained from 60 patients Who had been diagnosed with pulmonary carcinoma（ confirmed by pathology） by S-P immunohistochemical staining and the expression of glucotransporter-1 protein was detected, The result was analyzed with chis-quare criterion and exact probability which was computed by SPSS 13.0. Results：There was statistical significance in GLUT-1 between lung normal tissue,atypical hyperplasia and the pulmonary carcinoma tissue and between the pulmonary＇s normal tissue and epidermoid and deep lamella of pulmonary carcinoma and between pathology of pulmonary squamous carcinoma and in aversion of lymphaden of pulmonary squamous carcinoma（P 〈 0.05）. Conclusion：GLUT-1 may play an important role in the outgrowth and development of pulmonary carcinoma, which can be seen as an important index of diagnosis and prognostic assessment of pulmonary carcinoma.