早期诊断宫颈上皮内病变及宫颈鳞癌的标记物——Ki-67

Ki-67——the marker of early diagnosis of cervical intraepithelial neoplasia and cervical squamous carcinoma

目的:探讨宫颈上皮内病变及宫颈鳞癌的标记物——Ki-67的表达及意义。方法:应用免疫组化S-P法检测14例宫颈鳞癌、77例宫颈上皮内病变、23例正常宫颈组织中Ki-67的表达水平,并加以分析。结果:①Ki-67阳性表达率在宫颈鳞癌中最高(100%),宫颈上皮内病变次之(93.33%～100%),正常宫颈组最低(39.13%)。宫颈上皮内病变及宫颈鳞癌与正常组比较,差异有统计学意义(P<0.01)。②从正常宫颈组织、宫颈上皮内病变到宫颈鳞癌,Ki-67的表达强度逐渐增强,两者呈正相关(r=0.7708)。结论:Ki-67参与宫颈上皮内病变、宫颈鳞癌的发生。作为早期诊断宫颈上皮内病变及宫颈鳞癌的标记物,Ki-67的检测可提高宫颈鳞癌的早期诊断率。

Objective： To investigate the expression and significance of Ki-67 - a marker of the cervical intraepithelial neoplasia and cervical squamous carcinoma. Methods： Immunohistochemical S-P assay was used to detect the expression of Ki-67 in 14 cases cervical squamous carcinoma and 77 cases cervical intraepithelial neoplasia and 25 cases normal cervix. Results： （1）The positive expression rates of Ki-67 in cervical squamous carcinoma, cervical intraepithelial neoplasia and normal cervix were 100%, 93.33%-100% and 39.13% respectively, and it showed a significant difference compared with normal cervix group（P〈0.01）. （2）The expression intensity order of Ki-67 was normal cervix, cervical intraepithelial neoplasia and cervical squamous carcinoma from down to up, and they were in a positive correlation（r=0.770 8）. Conclusion： Ki-67 involves in the occurrence of cervical intraepithelial neoplasia and cervical squamous carcinoma. As a marker of early diagnosis of cervical intraepithelial neoplasia and cervical squamous carcinoma, the determination of Ki-67 could enhance the early diagnosis rate.