同期放化疗治疗中晚期鼻咽癌的疗效观察

Therapeutic results of concurrent chemoradiotherapy on patients with advanced nasopharyngeal carcinoma

目的:探讨同期放化疗治疗中晚期鼻咽癌(Ⅲ或Ⅳa期)的疗效。方法:回顾分析116例中晚期鼻咽癌的随访资料,根据治疗方法不同分为同期放化疗联合组(A组)和单纯放疗组(B组)。结果:同期放化疗联合组在肿瘤的消失方面明显高于单纯放疗组,两者差异有统计学意义(P<0.05)。放化疗联合组1、3、5年的生存率明显高于单纯放疗组,两者差异均有统计学意义(P<0.05);化疗最常见的不良反应为骨髓抑制和消化道反应,无Ⅲ度以上的不良反应和化疗相关死亡。放疗的不良反应主要为轻度骨髓抑制和口腔黏膜及皮肤反应,但无中途停止和放疗相关死亡。结论:同期放化疗治疗中晚期(Ⅲ或Ⅳa期)鼻咽癌是目前较为理想的治疗方案。

Objective： To explore the effect of radiotherapy combined with concurrent chemotherapy for the treatment of advanced nasopharyngeal carcinoma （stage Ⅲ and Ⅳa）.Methods：Data of 116 advanced nasopharyngeal carcinoma patients were analyzed retrospectively. The patients were divided into two groups based on different treatment methods. Group A received radiotherapy with concurrent chemotherapy, while group B received radiotherapy only.Results： The complete response rates of primary tumor in group A were more effective than those in group B（P〈0.05）. One, three and five-year survival rates of group A were significant higher than those of group B respectively （P〈0.05）. The most common toxicities were digestive tract effect and neutropenia.There were no grade 4 clinical toxicity and treatment-related death in the series. Systemic adverse effects frequently occurred during radiotherapy were esophagitis, Oral mucosa and cutaneous reaction, which were tolerable.Conclusion： Radiotherapy with concurrent chemotherapy is currently an effective method in the treatment of advanced nasopharyngeal carcinoma（stage Ⅲ and Ⅳa）.