评价86例溃疡性结肠炎患者血清中C反应蛋白临床疗效价值

Evaluation of clinical curative effect of the 86 ulcerative colitis patients and the C-reactive protein

目的:检测不同严重程度的溃疡性结肠炎(UC)患者外周血C反应蛋白(CRP)水平,评估其对UC患者临床严重程度的价值。方法:对UC患者86例以及健康对照42例,采集外周血,检测血清CRP、血沉及其他生化指标(肝功能、肾功能、免疫球蛋白)水平,重点分析CRP在不同临床时期的变化,并评估其与其他临床指标之间的相关性。结果:活动性UC患者血清CRP浓度明显高于健康人(P<0.01)。重度UC患者血清CRP水平显著高于中度UC患者有效药物治疗后,血清CRP水平呈明显下降(P<0.05)。相关分析发现活动性UC患者的临床严重程度与血清CRP水平之间呈正相关关系(r=91,P<0.01),而其他实验室指标(如ESR、肝功能、肾功能、免疫球蛋白)之间无明显相关性(P>0.05)。结论:CRP水平变化可以准确地反映UC患者临床严重程度,为临床上治疗,控制病情发展,以及判断预后提供了重要的理论依据。

Objective：To check the level of peripheral blood C-reactive protein on the UC patients of different severity order, and appraise the value of the UC patients. Methods：To compare 86 UC patients with 42 healthy persons, collect peripheral blood, test serum CRP, ESR and other biochemistry standard such as liver function, kidney function immune globulin. To analyze the CRP change in different clinical period and evaluate its relevance with other clinical standard. Results：The CRP concentration of active UC patient was obviously higher than that of healthy persons （P〈0.01）. The serum CRP level of severe UC patient was obviously higher than that ofthe less severe patients. After relative treatments, the serum CRP level dropped quickly （P〈0.05）. The analysis showed a positive relation（r=9） ,P〈0.01） of the sever level of active UC patients and the CRP, and no obvious relation （P〉0.05）with other laboratory standard such as ESR, liver function, kidney function immune globulin. Conclusion ：The change of CRP level can accurately reflect the severiey of UC patient, and offers theory basis for clinical treatment, patient＇s condition control.