高同型半胱氨酸血症与颈动脉硬化、脑梗塞关系探讨

Correlation between homocysteinemia and carotid artery arteriosclerosis with cerebral infarction

目的:研究同型半胱氨酸(Hcy)与颈动脉硬化(AS)的关系,探讨其对脑梗塞的预测价值。方法:对44例脑梗塞患者(脑梗塞组)与40例健康体检者(对照组)采用酶转换法进行Hcy水平测定,并行颈动脉多普勒彩超及脑CT检测。结果:脑梗塞组和对照组空腹血桨Hcy水平升高分别有39例(46.79%)和7例(17.5%),血浆Hcy含量分别为(19.53±6.02)和(11.24±2.31)μmol/L,二者比较有显著差异(P<0.05)。结论:高同型半胱氨酸血症是颈动脉硬化的独立危险因素,且对脑梗塞有一定预测作用。

Objective： To investigate the correlation between homocysteinemia （Hcy） and carotid artery arteriosclerosis （AS） with cerebral infarction. Methods： Measured the levels of homocgsteine with enzyme conversion method in 84 patients with cerebral infarction （Cl, Cl group） and 40 health check-up cases （control group）. The carotid artery was examined by color eehocardiography and the brain was examined by CT. Results： The homoeysteinemin possessed 46.49% in CI group, and 17.5% in control group. The plasma Hcy level respectively was （19.53±6.02） μmol/L, （11.24±2.31） μmol/L in CI group and control group （P〈0. 05）. Conclusion： The homocysteinemia is risk factor for carotid artery arteriosclerosis, and have prediction function for cerebral infarction.