摘要
目的:比较美托洛尔与地尔硫卓治疗心肌反复梗塞病人的疗效。方法:44例急性心肌反复梗塞患者随机分成两组,一组给予美托洛尔6.25mg,口服,1次/d,另一组给地尔硫卓30mg,口服,1次/d。疗程均为1个月。结果:两组患者短期死亡率没有明显差别(P>0.05),美托洛尔组的疼痛症状缓解,疼痛再发和心衰的减少均显著优于地尔硫卓组(P<0.05)。结论:小剂量美托洛尔选择性阻断β1受体,降低心肌的耗氧量,有对抗儿茶酚胺的心脏毒性作用,在防止心肌梗塞的面积扩大和改善症状方面优于地硫尔卓,其长期效果仍需继续观察。
Objective： To investigate the effect of metoprolol compared with diltiazem in patients with myocardium Infarction repeatedly. Methods： The 44 patients with repeated myocardium infarction randomly divided into two groups. The metoprolol group applies 6.25mg metoprolol, 2 times/d. The diltiazem group applies 30mg diltiazem, 3 times/d. Course of treatment was a month all. Results： There was no significant difference between two groups about the death rate of short-term （P〉0.05）. The symptomatic relief of pain and pain recur attack, heart failure decrease in metoprolol group were more than those of diltiazem group （P〈0. 05 all）. Conclusion： Minidose metoprolol can improve symptoms and decreases heart failure.
出处
《心血管康复医学杂志》
CAS
2008年第4期376-378,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
美托洛尔
地尔硫卓
心肌梗塞
Metoprolol
Dildazem
Myocardium infarction
