蒙药消肿散涂膜剂皮肤刺激和皮肤过敏实验研究

Study of the skin irritation and skin allergenic effect of XIAOZHONGSAN paint

目的对消肿散涂膜剂皮肤的刺激性和致敏性进行了动物实验观察。方法以家兔为模型进行一次给药皮肤刺激和多次给药皮肤刺激实验,以豚鼠为模型观察涂膜剂的皮肤致敏作用。结果消肿散涂膜剂对家兔皮肤未见任何刺激作用,也不引起豚鼠出现过敏反应。结论消肿散涂膜剂是一种安全性很高的外用新剂型。

Objective To study the skin irritation and skin allergenie effeet of XIAOZHONGSAN paint. Methods Onee and multiple dosing skin irritation test was earried out with rabbit model,and skin sensitization experiment was observed with guinea pig. Results XIAOZHONGSAN paint had no any irritant effeet on rabbit skin and no allergie response indueed in guinea pig. Conclutions XIAOZHONGSAN paint is a safety agent for external applieation.