摘要
脂氧素（lipoxin，LX）是继前列腺素和白三烯后被证实的又一重要花生四烯酸代谢产物，新近的研究发现LX对多种炎性细胞的功能和炎症相关基因的表达起广泛调节作用，能促进炎症反应的及时消退，被认为是机体内重要的内源性脂质抗炎介质，誉为炎症反应的“刹车信号（brakingsignals）”或“停止信号（stop signals）。
出处
《中华胰腺病杂志》
CAS
2008年第4期275-276,共2页
Chinese Journal of Pancreatology
基金
浙江省自然基金（Y205026）
同被引文献8
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1O'Sullivan TP, Vallin KS, Shah ST, et al. Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities. J Med Chem,2007,50 : 5894 -5902.
-
2Gilroy DW, Lawrence T, Perretti M, et al. Inflammatory resolution : new opportunities for drug discovery, Nat Rev Drug Diseov, 2004, 3:401-416.
-
3Schmidt J, Rattner DW, Lewandrowski K,et al. A better model of acute pancreatitis for evaluating therapy. Ann Surg, 1992,215:44- 56.
-
4Mota R, Sanchez-Bueno F, Berenguer-Pina J J, et al. Therapeutic treatment with poly (ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury. Br J Pharmaco1,2007,151,998-1005.
-
5Chiang N, Arita M, Serhan CN. Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX. Prostaglandins Leukot Essent Fatty Acids,2005,73:163-177.
-
6Ye XH, Wu Y, Guo PP, et al. Lipoxin A4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion. Brain Res,2010, 1323:174-183.
-
7Kure I, Nishiumi S, Nishitani Y, et al. Lipoxin A (4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor- kappaB activation. J Pharmaeol ExpTher,2010,332:541-548.
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8JinSW, Zhang L, Lian QQ, et al. Posttreatment with aspirin triggered lipoxin A (4) analog attenuates lipopolysaccharide induced acute lung injury in mice: the role of heme oxygenase-1. Anesth Analg,2007 ,104 :369-377.
-
1张力,万敬员,叶笃筠.脂氧素与炎症消退[J].生命的化学,2004,24(1):61-63. 被引量：31
-
2谭琰,邹开芳.脂氧素——炎症性肠病治疗的新契机[J].胃肠病学,2007,12(2):117-119.
-
3黄克俭,花天放.花生四烯酸代谢产物与急性呼吸窘迫综合征[J].肠外与肠内营养,1997,4(2):107-109. 被引量：1
-
4郭歌,祖凌云,高炜.花生四烯酸代谢产物与动脉粥样硬化[J].心血管病学进展,2014,35(5):526-530. 被引量：17
-
5杨鲁渤,李光明,张庆成,梅琪,王沪军,户萍.冠心病患者血浆花生四烯酸代谢产物的临床研究[J].医学综述,1997,3(11):542-543. 被引量：1
-
6周新泽,陈玉泉,沈洪薰,于秀,陈瑞新.急性胰腺炎大鼠氧自由基和花生四烯酸代谢产物的变化及维生素E的治疗作用[J].中华医学杂志,1997,77(2):150-151. 被引量：6
-
7胡波,牛彤.诱导痰中IL-8和中性粒细胞在支气管哮喘发病中作用的研究[J].北华大学学报（自然科学版）,2002,3(2):116-118.
-
8李明华.花生四烯酸代谢产物与支气管哮喘[J].国外医学（生理病理科学与临床分册）,1989,9(4):175-177.
-
9钟玉玲,谢玉波,马利.脂氧素A_4在心肌缺血再灌注损伤中的作用机制[J].广东医学,2014,35(18):2934-2936. 被引量：3
-
10马利,黄中华,梁宁.炎症调控介质-脂氧素的研究进展[J].中国临床新医学,2010,3(1):92-94. 被引量：2
