转化生长因子β1在血管损伤后再狭窄形成中的作用

Role of transforming growth factor beta 1 in the formation of restenosis following vascular injury

转化生长因子β1是一种高度多效、多功能性的生长与分化因子,它广泛地调节机体的生长、发育、炎症、修复和免疫等许多生理和病理过程。当血管损伤后,局部产生的细胞因子引起炎症反应是血管再狭窄的主要原因。其中,转化生长因子β1在局部水平上调刺激平滑肌细胞增殖和迁移、促进动脉外膜细胞的表型改变和迁移以及局部细胞外基质蛋白的产生和沉积,从而促进血管再狭窄。本文从转化生长因子β1的生物学特性、血管损伤后再狭窄的病理学、转化生长因子β1与血管损伤后再狭窄相关性及转化生长因子β1对血管损伤后再狭窄的作用机制等方面进行综述,说明转化生长因子β1在血管损伤后再狭窄病理过程中所起的作用。

Transforming growth factor β （TGF-β 1） is a growth and differentiation factor with highly multi-effect and multi-function, it widely regulates many physiological and pathological processes, such as body＇s growth, development, inflammation, repair and immune. The vascular restenosis is attributable to a local inflammation after vascular injury, which results in the production of cytokines. TGF-β1 in the local level can stimulate the proliferation and migration of smooth muscle cells, and promote the phenotypic transition and migration of adventitial cells, as well as production and deposition of local extracellular matrix protein, thus promoting vascular restenosis. This article attempts to investigate the role of TGF- β1 in restenosis after pathological vascular injury by the biological characteristics of TGF-β1, pathology of vascular restenosis, relationship between TGF- β1 and vascular restenosis, as well as the mechanism of TGF- β 1 on restenosis after vascular injury.