碱性成纤维细胞生长因子与骨折后的组织修复重建

Influence of basic fibroblast growth factor on tissue repair and reconstruction after fracture

学术背景:碱性成纤维细胞生长因子广泛存在于人体各种组织中,在体内参与多种组织的创伤修复过程,是体内重要的创伤愈合因子之一。目的:总结碱性成纤维细胞生长因子在骨折愈合过程中作用的研究进展。检索策略:应用计算机检索Pubmed数据库2000-01/2007-12期间碱性成纤维细胞生长因子在骨折愈合过程中作用相关的文章,检索词为"fibroblast growth factor2(basic fibroblast growth factor),fracture healing;regulation,signal transduction",并限定文章语言种类为"English"。同时计算机检索中国期刊全文数据库、万方数据库2000-01/2007-12期间的相关文章,检索词为"碱性成纤维细胞生长因子,骨折愈合,调控,信号传导"。排除标准:重复性研究和缺乏原创性的研究。文献评价:经过筛选共收集到33篇文献。有关碱性成纤维细胞生长因子的分布3篇、生物学特性3篇和加速骨折愈合作用27篇文章。资料综合:骨愈合实质是骨损伤后的再生过程,也是骨组织的形成过程。碱性成纤维细胞生长因子可通过其趋化作用促进细胞迁移,使间充质细胞、巨噬细胞、成纤维细胞等向创伤部位聚集,从而启动创伤愈合过程。目前关于碱性成纤维细胞生长因子的动物实验研究已比较深入,临床应用也有报道,其在骨折愈合中的作用也逐渐的明朗,碱性成纤维细胞生长因子通过调节细胞增殖、分化并改变细胞产物的合成而作用于成骨过程,不仅能促进骨细胞的生长,且能促进成骨细胞与支架材料的黏附。结论:①碱性成纤维细胞生长因子的分布、生物学特性已被初步认识,其加速骨折的愈合的研究也进一步的深入。②碱性成纤维细胞生长因子及相关载体复合而成的骨修复材料已进入实验阶段,并有待进一步的研究。

BACKGROUND： Basic fibroblast growth factor （BFGF） widely in human tissue participates in trauma repair of various tissues and is one of wound healing factors in the body. OBJECTIVE： To summarize the progress of BFGF in the fracture healing. RETRIEVAL STRATEGY： A computer-based online search of Pubmed Database was undertaken to identify the relevant articles on BFGF in the fracture healing published from January 2000 to December 2007 with the key words of ＂fibroblast growth factor 2 （basic fibroblast growth factor）, fracture healing, regulation, signal transduction＂ in English. At the same time, Chinese relevant articles were searched in China Journal Full-text Database （CJFD） and Wanfang Database published between January 2000 and December 2007 with the same key words in Chinese. Exclusive criteria included articles with repetitive research and non-original study. LITERATURE EVALUATION： A total of 33 articles were collected about the distribution （3 articles）, biological characteristics （3 articles） and the effect on the healing of bone fracture （27 articles） of BFGF. DATA SYNTHESIS： Bone healing is the process of regeneration after bone injury and the process of bone formation. BFGF can promote the cell migration by its chemotaxis and accelerate the healing by aggregating mesenchymal stem cells, macrophage and fibroblasts towards trauma region. Present animal studies on BFGF are deep and reports on clinical application are a few. Thus, the effect of BFGF is available. BGFG can affect bone formation by adjusting cell prolifeation and differentiation and changing the synthesis of cell products. BGFG not only can promote the bone growth, but also enhance the adhesion of osteoblasts and scaffold. CONCLUSION： The distribution and biological characteristics of BGFG have been recognized primarily. The further study on modulatory mechanism in the fracture healing of BFGF is carrying through. The bone restoration compounded by BFGF and its carders is in the experiment and needs to be studied further.