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芳基烃受体及其转录调控的细胞色素P4501A在环境污染物所致毒性中的作用 被引量：3

Roles of aryl hydrocarbon receptor regulating cytochrome P-450 1A in toxic responses caused by environmental pollutants
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摘要 芳基烃受体属于碱性螺旋-环-螺旋蛋白超家族的转录因子。环境污染物激活芳基烃受体,上调cyp1a的表达,诱导自身的Ⅰ相代谢,增加代谢中间体的生成,代谢中间体与生物大分子结合,造成机体损伤。环境污染物同时可激活芳基烃受体并改变一系列与细胞增殖、细胞周期进程和凋亡相关基因的表达,导致机体损伤并诱发肿瘤。 Aryl hydrocarbon receptor （AhR） is a member of the basic helix-loop-helix/Per-Arnt-Sim （bHLH/PAS） superfamily. Environmental pollutants upregulate cypla by activating AhR, and increase the production of intermediates by inducing the phaseⅠ metabolism of themselves. Intermediates conjugating with biomacromolecule cause injury. AhR activated by environmental pollutants modifies a series of geneexpression involved in cell proliferation, cell cycle and apoptosis, which cause injury and cancer.
作者 叶旋 王宇光 高月
机构地区 军事医学科学院放射与辐射医学研究所
出处 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2008年第4期316-320,共5页 Chinese Journal of Pharmacology and Toxicology
关键词 受体 芳基烃 细胞色素P450 1A1 细胞色素P450 1A2 receptors, aryl hydrocarbon cytochrome P-450 1Al cytochrome P-450 1A2
分类号 X171 [环境科学与工程—环境科学]
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参考文献25

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同被引文献28

  • 1朱立勤,娄建石.细胞色素P450与药物代谢的研究现状[J].中国临床药理学与治疗学,2004,9(10):1081-1086. 被引量：51
  • 2周小华,韩晓.AhR途径,CYP1A1、CYP1B1,雌激素代谢及作用过程中的调节[J].医学分子生物学杂志,2005,2(3):236-239. 被引量：8
  • 3王和芳,黄春新.时辰药代动力学研究进展[J].中国热带医学,2005,5(6):1342-1344. 被引量：5
  • 4黄长江,胡晓蓉,董巧香.苯并[a]芘对罗非鱼肝脏抗氧化防御系统的影响[J].汕头大学学报（自然科学版）,2006,21(4):51-56. 被引量：4
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引证文献3

二级引证文献7

中国药理学与毒理学杂志
2008年 第4期

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