1Nicholson KM, Anderson NG. The protein kinase B/Akt signaling pathway in human malignancy. Cell signal, 2002, 14 (5) : 381- 395.
2Datta SR, Brunet A, Greenberg ME,et al. Cellular survival: a play in three Akts. Genes Dev, 1999, 13(22) : 2905-2927.
3Stokoe D, Stephens LR, Copeland T, et al. Dual role of phosphatidylinositol-3, 4, 5- trisphosphate in the activation of protein kinase B. Science, 1997, 277(5325) : 567-570.
4Alessi DR, Andjelkovic M, Caudwell B, et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J, 1996, 15(23) : 6541-6551.
5Toker A, Newton AC. Akt/ protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem, 2000, 275(12) : 8271-8274.
6Troussard AA, Mawji NM, Ong C, et al. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem, 2003, 278(25) : 22374-22378.
7Sato S, Fujita N, Tsumo T. Modulation of Akt kinase activity by binding to Hsp90. Proc Nail Acad Sci USA, 2000, 97(20) : 10832- 10837.
8Fruman DA, Meyers RE, Cantley LC. Phosphoinositide kinases Annu Rev B iochem, 1998, 67: 481-507.
9Viglietto G, Motti ML, Bruni P, et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent inhibtor of p27kipl by PKB /Akt- mediated phosphorylation in breast cancer. Nature Med, 2002, 8(10) : 1136-1144.
10Toker A, Cantley LC. Signalling through the lipid products of phosphorino- sitide-3-OH kinase. Nature, 1997, 387(6634) : 673- 676.