平阳霉素加地塞米松瘤内注射治疗口腔颌面部脉管畸形的临床研究

Study of local injection of pingyangmycin plus dexamethason in treat ment of vascular malformation of oral and maxillofacial region

目的:研究平阳霉素加地塞米松瘤内注射治疗口腔颌面部脉管畸形的效果。方法:将平阳霉素8mg+地塞米松注射液1ml+2%利多卡因注射液(1-2)ml+生理盐水(2-4)ml稀释成平阳霉素的浓度为(1-2)mg/ml,行瘤内注射至表面肿胀发白,每次平阳霉素用量不超过8mg,14天-21天复诊,未愈者重复注射。结果:随访6个月-2年,治愈210例,占76.09%,显效65例,占23.55%,无效:1例,占0.36%。总有效率99.64%。结论:平阳霉素加地塞米松局部注射治疗口腔颌面部脉管畸形,具有疗效显著、简便易行、安全可靠等优点,是脉管畸形治疗的首选方法。

Objective： To study the treatment effect on vascular malformation of oral and maxillofacial region with pingyangmycin plus dexamethason by local injection. Methods： 8mg of pingyangmycin was dissolved in 2 -4 of normal saline ,5mg（ 1 ml） of dexamethason and 1 - 2ml of 2% lidocaine, concentration of pingyangmycin was 1 - 2mg/ ml. Pingyangmycin solution was injected into hemangioma until it began to swell and got pale with a dose less than 8mg. If patient was not cured after 14 -21 days, inject again. Re.suits：After 6 months to 2 years,the cure rate was 76.09% ,the effective rate was 23.55% ,the ineffective rate was 0.36%. The total effective rate was 99.64%. Conclusion： The treatment effect is reliable, prominent and safe. It is easily operated, and recommendable therapy for vascular malformation of oral and maxillofaeial region.