Galectin-3在乳腺浸润性导管癌中的表达及其意义

Expression of Galectin-3 and its clinicopathological significance in invasive ductal carcinoma(IDC)of breast

目的:检测Galectin-3在乳腺浸润性导管癌(IDC)中的表达情况,并探讨其在IDC进展过程中的意义。方法:应用组织芯片技术和免疫组织化学方法研究101例乳腺IDC和37例乳腺良性病变中Galectin-3的表达情况。并统计分析其与年龄、肿块最大径、组织学分级、TNM分期以及淋巴结转移间关系。结果:Ga-lectin-3在乳腺IDC和良性病变中的表达强度具有显著差异(P=0.000)。在IDC组,Galectin-3表达与淋巴结转移(rs=0.337,P=0.001)和TNM分期(rs=0.269,P=0.007)呈正相关,而与年龄、肿瘤直径以及组织学分级无关。结论:Galectin-3表达水平在乳腺良、恶性病变中明显不同;Galectin-3高表达的乳腺IDC具有更高侵袭性和淋巴结转移能力;对Galectin-3作用机制的深入研究有可能使其成为乳腺IDC患者个体化治疗的新靶点。

Objective： To investigate the relationship between expression of Galeetin -3 and elinieopathologieal findings in patients with IDC of breast. Methods： Immunohistoehemieal assessment of Galeetin -3 expression was performed on a tissue mieroarray containing 101 IDC eases and 29 fibroadenoma cases, 8 adenosis cases. Furthermore, their relationship with elinieopathologieal factors such as age, T stage, TNM stage, differentiation, lymph node metastasis and so on were considered from a statistical viewpoint. Results： Expression level of Galectin - 3 protein （ P =0. 000） in benign and malignant breast lesions were significantly different. In 101 IDC samples, immunohisto- chemical staining against galeetin -3 in 101 IDC specimens showed significant positive correlation between galectin - 3 expression and axillary lymph node metastasis（rs =0. 337, P =0.001 ） and TNM stage （r, = 0.269,P = 0.007 ）, other than age, differentiation and T stage. Conclusion ： This study demonstrates that expression intensity of Galeetin -3 is different obviously in benign and malignant lesions of breast; High expression level of Galeetin -3 suggests strong ability of invasion and metastasis. These results may lead to the development of a therapeutic modality aiming at abrogating Galeetin -3 expression and thus hampering its activity during cancer progression and metastasis.