O^6-甲基鸟嘌呤-DNA-甲基转移酶(MGMT)在乳腺癌中的表达及其临床意义

Expressions of O^6 methylguanine-DNA methyltransferase(MGMT) in breast cancer and Its clinical significance

目的:研究DNA修复酶(O-methylguanine-DNA methyltransferase,MGMT)在乳腺癌中的表达及其临床意义。方法:乳腺癌和腺瘤标本共计143例,10%福尔马林固定,石蜡包埋,采用SABC免疫组织化学方法检测MGMT表达。结果:MGMT在乳腺癌和乳腺腺瘤中的阳性率分别为57.85%和13.64%,组间比较具有显著性差异。MGMT在乳腺癌中的表达与患者的年龄、淋巴结转移有关。结论:MGMT的异常表达与乳腺癌的淋巴结转移有关;MGMT可以作为判断乳癌发生和预后的重要指标;检测其表达可以指导临床上化疗方案的制定。

Objective： To investigate the expression of MGMT in breast cancer and its clinical significance. Methods： Total of 143 specimens from breast adenoma and breast cancer were tested by immunohistochemical technique MGMT. Results： The positive rate of MGMT in breast cancer was 57.85% ,while 13.64% in breast adenoma, there was significant difference between the two groups. The expression of MGMT was correlated with the patients＇age and lymph node metastasis. Conclusion： Abnormal expression of MGMT was associated with lymph node metastasis; It could be a useful index for the primary screening and the prognosis of breast cancer.