EGFR/HER_1和C-erb B-2/HER_2在乳腺癌表达的意义及其相关性

Clinical significance and their relation of EGFR and C-erb B-2 expression in breast carcinoma

目的:探讨乳腺癌中EGFR和C-erb B-2基因蛋白表达的临床意义。方法:乳腺癌86例,乳腺腺瘤36例,采用免疫组织化学方法,检测EGFR/HER1和C-erb B-2/HER2阳性率,分析它们的相关性。结果:EGFR和C-erb B-2在乳腺癌中的表达高度正相关(r=0.73)。它们在乳腺癌中的阳性率明显高于腺瘤(P<0.001)。在乳腺癌中EGFR和C-erb B-2的阳性率分别为56.98%(49/86)和70.93%(61/86),差异无显著性(P>0.05)。在浸润癌和有淋巴结转移组阳性率高于非浸润组和无淋巴结转移组(P<0.001)。结论:EGFR和C-erbB-2在乳腺癌发生中有协同作用,是预后不良的指标。

Objective： To study the significance of epidermal growth factor receptor （ EGFR/HER1） and C - erb B - 2 （ HER2 ） gene protien overexpression in breast carcinoma. Methods ： Thirty six cases of adenoma and 86 cases of breast cancer were detected by SP immunohistochemistry. The relation of their expression were analysed. Results ： EGFR was correlated with C - erb B - 2 in breast carcinoma （ r = 0.70）. The positive rates of EGFR and C - erb B - 2 were 56.98 % （49/86） and 70.93 （ 61/86 ） （ P 〉 0.05 ）. The expression rates of EGFR and C - erb B - 2 in the group of lymphnode metastasis and group of invasive cancer were higher than nonlymphnode metastasis and noninivasive cancer（ P 〈 0.01 ）. Conclusion： The EGFR and C -erb B -2 have combined effect for occurrence of breast cancer and they are predictive factors for breast cancer.