国产吉西他滨联合顺铂治疗63例晚期非小细胞肺癌的临床观察

Clinical observation of gemcitabine plus cisplatin in treatment of 63 cases advanced of non-small cell lung cancer

目的:评价吉西他滨联合顺铂治疗晚期非小细胞肺癌的疗效和毒性。方法:60例患者采用吉西他滨1000mg/m2,iv,d1,8,顺铂75mg/m2,iv,d1或25mg/m2,iv,d1-3化疗。每3周期评价疗效。结果:初治病例RR44.6%,复治病例RR30.8%。主要不良反应为骨髓抑制。结论:吉西他滨联合顺铂治疗晚期非小细胞肺癌具有较高有效率,毒性可以耐受。

Objective： To evaluate the curative effect and toxicity of gemcitabine combined with cisplatine in treatment of advanced non - small cell lung cancer. Methods. Sixty three cases were treated with gemcitabine1000mg/m^2 Ⅳ on day 1,8,and cisplatin 75mg/m^2 Ⅳ on dayl or 25mg/m^2 Ⅳ on day 1,2,3, repeated every 3 weeks and the clinical response was assesed after three cycles. Results： Effective rate of patients with primary treatment was 44. 6% , effective rate of patints previously treated was 30.8%. The principal toxicity was inhibition of bone marrow. Conclusion： Gemcitabine combined with cisplatine shows a better therapeutic effect in treatment of advanced non - small cell lung cancer,and toxicity is tolerant.