中国汉族NOS2基因多态性与白癜风发病相关性研究

Study on the association between NOS2 polymorphism and vitiligo

目的:探讨NOS2基因-954G→C位点多态性与白癜风发病的相关性。方法:采用聚合酶链反应和限制性片段长度多态性方法,对749例白癜风患者和763例健康人的NOS2基因-954G→C位点基因型进行分析。结果:白癜风患者NOS2-954G→C位点基因型的分布与正常对照组相比有显著性差异,联合基因型GC+CC及C等位基因在白癜风患者中频率较高,与临床资料结合分析表明联合基因型GC+CC在在发病年龄大于20岁组、活动期患者、皮节型白癜风及伴有自身免疫病和正常对照组之间无显著差异(P>0.05),但在发病年龄小于20岁组、稳定期患者、寻常型白癜风及无自身免疫病组的分布频率与正常对照组相比有显著性差异(P<0.05)。结论:NOS2-954G→C位点基因多态性与白癜风有明显的相关性。携带C等位基因可能会增加对白癜风的易感性。

Objective Objective to investigate the association between NOS2-954 G→C polymorphism and vitiligo in Han Chinese people. Methods NOS2-954 genotypes of 749 vitiligo patients and 763 healthy controls were tested by PCR-RFLP. Results We found a statistical significant association between NOS2-954 C allele and vitiligo （P〈0.05）. Conclusion NOS2 -954 polymorphism is association with vitiligo.The C allele will increase the susceptibility of vitiligo.