细胞因子诱导的杀伤细胞在肿瘤过继免疫治疗中的研究进展

Research progress in the application of cytokine-induced killer cells to cancer adoptive immunotherapy

细胞因子诱导的杀伤细胞(CIK)是人外周血单个核细胞在体外经多种细胞因子刺激后获得的异质细胞,兼具有T淋巴细胞的强大抗瘤活性和自然杀伤细胞(NK)非主要组织相容性复合体(MHC)限制杀瘤特点。与淋巴因子激活的杀伤细胞、肿瘤浸润性淋巴细胞和CD3AK细胞相比,CIK细胞具有独特的优势,其在过继性免疫治疗中的应用得到了广泛研究。文中综述了近年来C IK在与树突细胞、双特异性抗体、溶瘤病毒相互作用及在基因转染等方面的研究进展。

Cytokine-induced killer （CIK） cells are heterogeneous lymphocytes generated by incubation of human peripheral blood mononuclear cells with various cytokines in vitro, characterized by both the T lymphocyte＇s powerful cytotoxic activity and the natural killer （NK） cell＇s non-major histocompatibility-restricted antitumor activity in vitro and in vivo. CIK cells have their peculiar superiority over standard lymphokine activated killer （LAK） cells, tumor-infiltration lymphocytes （TIL） and anti-CD3 antibody induced activated killer （CD3AK） cells in application to the cancer adoptive immunotherapy and have hence received wide attention from researchers. This article updates recent researches on CIK cells, their interaction with dendritic cells, bispecific antibodies and oncolytic viruses, as well as their use in gene transfer.