强心益气汤对急性心力衰竭模型家兔的作用

Preventive and Therapeutic Effects of Qiangxinyiqi Decoction (强心益气汤) on Rabbits with Acute Heart Failure

目的:探讨强心益气汤对家兔急性心衰模型的作用。方法:将兔分为防治组(造模前后均灌服强心益气汤)、治疗组(造模前灌服蒸馏水,造模后灌服强心益气汤)和对照组(造模前后均灌服蒸馏水),观察各组造模所需时间和所需戊巴比妥钠用量,测定造模前后兔的血流动力学指标。用恒速滴注戊巴比妥钠的方法建立兔急性心力衰竭模型,测定各组造模成功时造模剂用量及造模时间,观察血流动力学指标。结果:(1)强心益气汤能使戊巴比妥钠所致家兔急性心力衰竭模型形成所需的时间和用药量明显增加,血流动力学指标lv±dp/dtmax、lv+dp/dtmax、lv-dp/dtmax改善。结论:强心益气汤对急性心力衰竭模型兔能改善心室舒缩功能,降低外周阻力,改善心衰程度。

Objective： To investigate the preventive and therapeutic effects of Qiangxinyiqi Decoction （QXYQD） on the cardiac functions of rabbitswith acute heart failure. Methods： The pure-bred New-Zealand rabbits were randomized into 3 groups：control group, duodenum administrated with QXYQD before and after modeling （observe group） ; duodenum administrated with purified water before modeling and with QXYQD after modeling. The differences of modeling time and dosage of pentobarbital sodium between groups were detected; hemodynamics parameters before and after administration were compared. Results： （ 1 ） The modeling time and dosage of pentobarbital sodium were remarkably increased in observe group , differences being significant compared other 2 groups（ P 〈0.01 ） ; （2） All the hemodynamics indications showed a recovering trend in 3 groups at different rates and to different extent. The recovering trend increased with administration time. Differences of lv ± dp/dtmax between groups were 30 minutes after administration（ P 〈 0.01 ） ; LVSP was increased and t-dp/dtmax shorted, the differences of LVSP being significant 60 minutes and 90 minutes after administration and that of t-dp/dtmax being significant 60 minutes after administration （ P 〈 0.05 ）. Conclusion： QXYQD has preventive effect on acute heart failure.