酒精性骨质疏松症发病机制的研究进展

Research progress on pathogenesis of alcohol-induced osteoporosis

酒精性骨质疏松症(AOP)是临床常见的酒精性骨病之一,且一直未得到人们的足够重视。本文主要总结AOP发病机制的研究进展,包括饮酒量与骨质疏松的关系,AOP的定义,中医学的主要病因病机和主要病理变化,说明了酒精对骨细胞、钙调节激素[包括1,25-二羟维生素D3(1,25-(OH)2-D3)、甲状旁腺激素(PTH)、降钙素(CT)]、肾上腺皮质类固醇激素、肝脏功能和营养的影响,并指出该病研究现状和存在问题,提示AOP需要进一步深入研究,而从中西医结合的角度研究将是一个新的研究方向和发展趋势。

Alcohol-Induced Osteoporosis （AOP） is one of common alcohol osteodystrophies in clinic, but has not yet received adequate attention of the people. This paper concluded AOP on the pathogenesis of progress, including the relationship between the drinking of alcohol and osteoporosis, AOP of the definition, The main cause of its disease and major pathological changes in TCM, Description of the alcohol on bone cells, calcium regulating hormones [ including 1,25-dihydroxy Vitamin D3 （ 1,25-（ OH）2-D3 ）, parathyroid hormone （PTH）, calcitonin （CT） ], adrenal Corticosteroid, liver function and the impact of nutrition, this paper also pointed out that the disease on the research status and problems, prompted AOP required further study, and forecasted research in the perspective of combination of TCM and Western Medicine was a new research direction and development trend.