乳腺癌中PTEN与MMP-9、P27kip1蛋白表达及其临床意义

Expression of PTEN,MMP-9 and P27kip1 in breast cancer and their clinical significance

目的:第10号染色体同源丢失性磷酸酶-张力蛋白基因(Phosphatase and tension homology deleted on chromosometen,PTEN)、基质金属蛋白酶(Matrix metalloproteinase9,MMP-9)、激酶抑制蛋白(Kinase inhibited protein1,P27kip1)在乳腺癌中的表达及其相关性,探讨三者的表达与临床分期、淋巴结转移及预后的关系。方法:选取50例有完整临床及病理资料的乳腺癌病例,采用SP免疫组织化学技术检测乳腺癌中PTEN、MMP-9、P27kip1蛋白的表达情况。结果:PTEN、MMP-9、P27kip1在乳腺癌中高表达率分别为54%、74%、62%。结论:PTEN、MMP-9、P27kip1在乳腺癌中的表达与患者的临床分期及淋巴结转移有关,可作为乳腺癌预后的参考指标。

Objective：To study the expression of PTEN,MMP-9 and P27kipl in breast cancer and their relationship,to investigate the relationship between their expression and the clinical stage,the metastasis of axillary lymph node and prognosis. Methods：50 cases of breast cancer with complete clinical and pathological material are selected and test the expression of PTEN,MMP-9,P27kipl by the SP immunohisto-chemical method. Results：The high expression rate of PTEN,MMP-9,P27kipl are54%,74%,62% respectively. Conclusion：The expression of PTEN,MMP-9,P27kipl in breast cance correlates with the clinical stage and the metastasis of axillary lymph node and can be used as the marker of patient＇s prognosis.