选择性心理干预对乳腺癌患者T细胞亚群和情绪的影响

Effects of selective psychological intervention on T lymphocyte and emotion in patients with breast cancer

目的:观察选择性心理干预对化疗期乳腺癌患者外周血T细胞亚群和焦虑抑郁情绪的影响。方法:采用随机对照研究方法,将60例乳腺癌住院病人分为心理干预组和对照组,2组病人给予常规化疗及健康教育,干预组同时进行选择性心理干预,患者每天自主选择和完成心理干预方法并在治疗作业表格上记录完成情况。观察治疗前后2组病人的外周T细胞亚群和焦虑抑郁情绪的变化情况。结果:外周T细胞亚群,干预组干预后CD3+、CD4+、CD4+/CD8+较干预前上升,CD8+较干预前下降,与对照组相比差异显著(P<0.01)。对照组治疗后CD3+、CD4+、CD4+/CD8+上升,CD8+下降,但差异不显著。HAMA、HAMD评分,干预后干预组与干预前及对照组相比差异显著(P<0.01),对照组治疗后评分较治疗前差异显著(P<0.05)。结论:选择性心理干预有提高化疗期乳腺癌患者外周血T细胞亚群和降低焦虑抑郁情绪的功能。

Objective：To study the role of selective psychological intervention on peripheral blood T lymphocyte subtypes and emotion in patients with breast cancer. Methods：Randomized-control study method was adopted. Sixty inpatients with breast cancer were divided into intervention group and control group（30 patients in each group）. Patients in both groups received routine chemotherapy and health education while the intervention group also received selective psychological intervention. Psychological intervention methods were selected independently and completed daily by patients in intervention group and completion status was also recorded daily on psycho-treatment form by them. Anxiety and depression of both groups were measured and peripheral blood T lymphocyte subtypes were detected pre- and post-treatment. Results：In intervention group CD3＋ CD4＋ and the ratio of CD4＋/CD8＋ of T lymphocyte subtypes were higher,while CD8＋ was lower after intervention than that before intervention. A significant difference was also observed compared to that of control group（P〈O.01）. In controlo group,though CD3＋ CD4＋ and the ratio of CD4＋/CD8＋ were higher and CD8＋ was lower in post-treatment period than that before treatment,there was no significant difference. In intervention group,HAMA HAMD value showed significant difference after intervention than that before intervention and that in control group（P〈0.01）. In control group HAMA HAMD value showed significant difference after treatment than that before treatment（P〈0.05）. Conclusion：Selective psychological intervention can enhance the function of peripheral blood T lymphocyte subtypes and decrease anxiety and depression,so as to improve the prognosis of patients with breast cancer during chemotherapy.