脂微球—前列腺素E1联合倍他乐克在心脏X综合征中的应用

目的观察静脉应用脂微球—前列腺素E1（Lipo-PGE1）联合口服倍他乐克对心脏X综合征患者心肌缺血、心脏功能的影响，评价其治疗效果。方法将49例心脏X综合征患者随机分为治疗组28例，在心脏X综合征常规治疗基础上加用静脉滴注Ljpo-PGE1，10ug/次，1次／天，联合口服倍他乐克6．25～125mg，2次／天，疗程7～10d；对照组为21例，常规综合治疗。观察治疗前后各组的临床疗效，对心肌缺血、心脏功能监测。结果治疗组与对照组在住院7～1Od内治疗总有效率分别为78．6％与47．6％（P〈0.01），治疗组在显效率（P〈0.01），改善心肌缺血水平（P〈0.01）和左心室舒张功能水平（P〈0．01）更显著。结论脂微球—前列腺素E1与倍他乐克合用对心脏X综合征有明显疗效，可提高患者生存质量，改善心脏舒张功能。

Objective To observe the clinical effect of Lipo-prostaglandin E1 （Lipo-pGE1）injection plus Betaloc on the Cardial ischemia and the heart function in patients with X-heart syndrome and to evaluate the efficacy. Methods 49patients with X-heart syndrome were randomly divided into a treatment group （n=28, Lipo-PGE1 10ug/d, iv drip plus Betaloc 6.25-12.5mg/Bid, po add conventional therapy ）and a control group （n=21, conventional therapy）.The whole therapeutic course was 7-10days. The cardial ischemia and the heart function were measured before and after treatment. Results The symptom improving rate was 78,6%.in treatment group and 47.6% in control group（P〈0.01）. The former raised the efficacy and improved the cardial ischemia and the left ventricular diastolic function obviously. Conclusion Efficacy of Lipo-PGE1 injection plus Betaloc on patients with X-heart syndrome was remarkable and safe.