染色体分析与浆膜腔积液的脱落细胞学检测

Chromosome Analysis and Exfoliative Cytology of Serous Effusion Examination

目的:探讨染色体分析在浆膜腔积液性质鉴别中的应用价值。方法:采用染色体制备分析法。本文对56例61次浆膜腔积液进行染色体分析,其结果与相应脱落细胞学相比较。结果:25例恶性积液中,染色体异常者23例,阳性率92%(23/25),细胞形态学检查阳性者22例,阳性符合率88%(22/25)。31例良性积液中,染色体检查均未见明显异常。其中3例染色体检查见4倍体,脱落细胞形态学检查有间皮细胞异形。结论:恶性浆膜腔积液中多有染色体数量和形态结构明显异常,结合脱落细胞形态学检查,有助于提高恶性肿瘤的阳性符合率。

Objective：To investigate the applicable value of serous effusion＇s chromosome analysis at the appreciation of fluidify quality. Methods： To adopt chromosome preparation analytical methods.The article was about serous effusion were examinated 61 times with chromosome analysis for 56 cases, the result was compared with correlative exfoliative cytology . Result：In the 25 malignant fluidify cases, the abnormal chromosomes were 23 cases, positive rate was 92 % （23/25） , cytomorphology examinational positive was 22 cases, the positive coincidence rate was 88 % （22/25）. Chromosomes were almost no obvious abnormal in 31 benign fluidify cases . Four ploid was found in 3 cases among chromosomes analysis, and abnormal mesothelial cells were found in exfoliative cytologic examination. Conclusion： Chromosomal＇ s quantity and morphology were almost obvious abnormal in the malignant serous effusion, combined exfoliative cytologic examination, these were conducive to raise the malignant tumor＇s positive coincidence rate.