摘要
目的探讨血清转化生长因子-β1(TGF-β1)、Ⅳ型胶原水平变化对糖尿病肾病的临床意义。方法TGF-β1和ST4C:ELISA法;尿白蛋白排泄率(UAER):散射比浊法。结果2型糖尿病合并糖尿病肾病组(DN组)TGF-β1和ST4C水平明显高于2型糖尿病合并糖尿病肾病组(DN组)和NG组,差异有非常显著性(P<0.01);DN组TGF-β1、ST4C与UAER存在较高的正相关性(r=0.4882、0.7414,P<0.01);DN组TGF-β1与ST4C有高度正相关性(r=0.6560,P<0.01);而DM组TGF-β1与ST4C相关性无显著意义(r=0.3419,P>0.01)。结论血清TGF-β1、ST4C与2型糖尿病合并糖尿病肾病组(DN组)肾损害高度相关,TGF-β1是DN的重要发病机制。
Objective To investigate clinical significance of serum TGF-β1 and IV collagens concen-tration change in diabetic nephropathy. Methods The concentrations of TGF-βand ST4C were detected with ELISA, urine albumin excretion rate was detected with Scattering turbidimetry. Results The concentrations of the serum TGF-β1 and ST4C in diabetic nephropathy were higher than those in DM and NG（P 〈0. 01 ）;TGF-β1, ST4C and UAER were positively correlated in DN, TGF-β1 and ST4 C were positively correlated in DN, TGF-β1 and ST4C were not correlated in DM. Conclusion TGF-β1 and ST4C may play the important role in patho-genesis of diabetic nephropathy, the diabetic patients are significantly higher than tlaosc in controls（P〈0.05）. The levels of the serum TGF-βl and Ⅳ collagens in group DN were significantly higher than those in group DM （ both P 〈 0. 05）.
出处
《中国实用医药》
2008年第22期21-22,共2页
China Practical Medicine
