复方丹参注射液和小剂量肝素治疗新生儿硬肿症(中重度)疗效分析

A study on compound salvia injection and low-dose Sodium Heparin in treating middle and serious neonatal scleredema

目的探讨复方丹参注射液和小剂量肝素对新生儿硬肿症（中、重度）的治疗效果。方法将61例新生儿硬肿症（中、重度）患儿随机分为治疗组32例,对照组29例,两组均采用暖箱复温、控制感染、补充足够能量及液体、纠正器官功能紊乱等。治疗组加用复方丹参注射液1-2ml/（kg·d）静脉滴注,1次/d。同时给予小剂量肝素10U/（kg.次）,1次/12h,皮下注射,疗程3-5d。结果总有效率治疗组为87.5%,对照组为62.1%,治疗组在体温恢复正常时间、硬肿消退时间、吮奶量及哭声增大时间、住院时间等均短于对照组,差异有统计学意义（P〈0.05）。结论复方丹参注射液和小剂量肝素对中、重度新生儿硬肿症疗效显著可靠,方便易行,值得在基层医院推广。

Objective To study the effect of compound salvia injection and low-dose Sodium Heparin on neonatal seleredema. Methods 61 cases with middle and serious neonatal seleredema were randomly divided into treatment group （32 cases） and control group （29 cases）. Both groups got some treatments such as recovery of temperature in the incubator, prevention of infection, reasonable provision of calory and liquid, and treatment of multiple organ dysfunction. The treatment group received additional intravenous injectional compound salvia 1-2 ml/（ kg·d） once a day and subcutaneous injectional Sodium Heparin 10 U/（ kg·dose）twice a day. The time of therapy are three to five days. Results The response rate were 87.5% in the treatment group and 62. 1%in the control group, respectively. The periods of temperature recovery, scleredema disappearing, sucking increasing and eying scale-up and the length of stay were shorter in the treatment group than those in the control group （P 〈 0. 05 ）. Conclusion Compound salvia injection and low-dose Sodium Heparin are effective in treating neonatal seleredema and it is reliable and convenient and should be used widely in basic level hospital.