聚乙二醇化干扰素治疗慢性丙型肝炎疗效预测及影响因素

Factors of predicting and influencing curative effectiveness in pegylated interferon treating chronic hepatitis C

聚乙二醇化干扰素联合利巴韦林（RBV）是目前公认的治疗慢性丙型肝炎的标准方案。综合分析患者特点及对治疗的反应，有助于临床医生进行疗效预测并优化治疗方案。此文主要从患者治疗前的基线因素、治疗中的血清病毒动力学变化及联合的RBV剂量等方面作以综述。

Pegylated interferon （Peg-IFN） plus ribavirin（RBV） achieves a higher sustained response rate in patients with chronic hepatitis C （CHC）, it is currently the standard treatment regiment. Synthetical analysis on patients＇ charaicteristics and responses to the treatment will be useful in predicting clinical effects and optimizing the treatment regimen. This article illustrates baseline factors before the patients＇ treatment, viral kinetics on-therapy, dose of RBV and so on.