多重耐药铜绿假单胞菌的主动外排机制

The effiux pump of multidrug resistant Pseudomonas aeruginosa

铜绿假单胞菌（PA）对多种抗菌药物都有不同程度的耐药，其耐药机制包括酶的产生、生物被膜的形成、外排泵的高表达和外膜孔蛋白表达的降低或缺失，其中多药外排泵能排出多种结构和功能不相关的抗菌药物，包括β-内酰胺类、氟喹诺酮类、大环内酯类、氨基糖苷类、四环素、氯霉素等，目前被认为是导致PA固有和获得性多重耐药的重要原因。

Pseudomonas aeruginosa is resistant to many antibacterical agents to different extent, its mechanisms involve generation enzymes, formation of biofilm, over expression of efflux pump, as well as low expression or even loss of porin, and muhidrug eftlux pump can eftlux many construction and fuction unrelated antibacterical agents, including β-lactam, fluoroquinolones, macrolides, aminoglycosides, tetracycline, chloramphenicol and so on. It is presumed as the main reason for the inherent and acquired multidrug resistance of Pseudomonas aeruginosa at present.