防耐药突变体选择浓度和耐药突变选择窗理论的研究进展

Research of mutant prevention concentration and mutant selection window

目的:阐述防耐药突变体选择浓度和耐药突变选择窗理论的最新研究进展。方法:查阅近年来国内外相关文献资料进行整理归纳。结果与结论:体外MPC测定、体外药效学研究、动物感染模型、人体内研究验证了MSW理论,防耐药突变体选择浓度和耐药突变选择窗理论为评价细菌耐药新的重要指标。

Objective： To review the recent research of mutant prevention concentration （MPC） and mutant selection window （MSW）. Methods： Pertinent literature about MPC and MSW was reviewed. Results and Conclusion： MPC and MSW theory was verified by MPC determination in vitro, pharmacodynamics in vitro, animal infectious model and studies in vivo. MPC and MSW theory is a new strategy to evaluate the bacterial resistance.