血清CEA、CA199及CA125联合检测对肺癌诊断临床价值的探讨

A study the clinical value of combined detection of serum CEA CA199 and CA125 in patient with lung cancer

目的探讨血清CEA、CA199及CA125联合检测在肺癌诊断、病情监测及其疗效观察中的价值。方法采用电化学发光技术检测30例正常对照组,45例肺癌患者血清CEA、CA199及CA125的含量,并对肺癌患者治疗前后3种肿瘤标志物的含量变化监测、随访。结果肺癌患者CEA、CA199及CA125的阳性率明显高于正常对照组(P<0.01),病人治疗后3种指标含量较治疗前明显下降(P<0.01),三者联合检测敏感性和准确性显著提高(P<0.05)。结论血清CEA、CA199及CA125联合检测有助于提高肺癌诊断的敏感性和准确性,同时对疗效观察及预后监测有重要意义。

Objective To study the value of combined detection of serum CEA CA199 and CA125 in diagnosis, and to monitor patient＇s condition and therapeutic effectiveness in patient with lung cancer. Methods Serum levels of CEA CA199 and CA125 were measured by eletrochemiluminescence assay in 30 healthy adults and 45 patients with lung cancer, after treatment. The levels of the three kinds of tumor marker in lung cancer were compared with those before treatment. Results. The levels of three kinds of tumor marker in the lung cancer group were obviously higher than those in the control group（ P 〈 0. 01 ）. The serum levels of three kinds of tumor marker in patient with lung cancer were significantly decreased after the treatment （P 〈 0. 01 ）. Both sensitivity and specificity of detection improved when the combined detection of CEA CA199 and CA125 was used （ P 〈 0.05 ）. Conclusion The combined detection of CEA CA199 and CA125 can significantly improve the sensitivity and specificity of lung cancer and also has a notable value in observing therapeutic effectiveness of lung cancer.