摘要
目的研究大肠癌患者血清抗核抗体(ANA)与白细胞介素-6(IL-6)的关系及临床意义。方法应用夹心酶联免疫分析法、荧光免疫测定法检测42例大肠癌患者术前、术后一周血清IL-6及ANA的水平,并以35例健康人做对照,对数据进行分析比较。结果大肠癌患者术前外周血清IL-6、ANA水平显著高于对照组(P<0.05);ANA阳性和阴性患者血清IL-6水平差异有统计学意义(P<0.05);肿瘤切除后血清IL-6水平明显降低(P<0.05);术后ANA降低不明显;ANA水平与肿瘤直径密切相关。结论IL-6、抗核抗体水平能反映大肠癌生物学行为情况,IL-6是引起抗核抗体升高的重要原因。
Objective To study the correlation of antinuclear antibody （ ANA ） and interleukin-6 （IL-6） with human colorectal cancer. Methods Levels of serum IL-6 and autoantibody were detected by sandwich ELISA and fluorescence immunoassay before and after operation in 42 colorectal cancer patients and 35 healthy people. Results Serum IL-6 and ANA levels in the colorectal cancer patients were significantly higher than control group （P〈0.05）. The levels of serum IL-6 in autoantibody positive patients were higher than that in negative patients（P〈0.05）. Serum IL-6 levels decreased significantly after operation（P〈0.05）. Serum autoantibody levels didn＇t decrease after operation significantly. Autoantibody levels were correlated with the cancer diameters. Conclusion IL-6 and antibody may be important parameters which reflecting the biological behavior of col- orectal cancer. IL-6 is a main factor for the improvement of expression of autoantibody.
出处
《中华普通外科学文献（电子版）》
2008年第4期35-36,共2页
Chinese Archives of General Surgery(Electronic Edition)
