大肠埃希菌耐药谱六年动态观察和分析

Analysis on changes of antibiotic resistance spectrum of Escherichia coli during past six years

目的了解广州地区大肠埃希菌检出情况及其对常用抗菌药物的耐药谱动态变化，为临床合理选用抗菌药物提供依据。方法应用回顾性调查方法，对本院从2002年1月～2007年12月间临床样本分离的大肠埃希菌的药敏试验进行对比统计分析。结果所分离出的679株大肠埃希菌，占革兰阴性菌的18．6％：大肠埃希菌对常用抗菌药物的耐药率总体呈上升趋势。耐药率低于30％的有亚胺培南、阿米卡星和哌拉西林／三唑巴坦。除了哌拉西林／三唑巴坦外其他抗菌药物耐药性均有显著性变化。结论本地区大肠埃希菌耐药率有显著性变化，多重耐药现象严重，动态监测其耐药谱变化，是防止大肠埃希菌的感染率攀升的重要措施。

Objective To investigate the changes of antibiotic resistance spectrum of Escherichia coli. Method Escherichia coli were isolated from clinical samples and their resistances to antibiotic in our hospital from jan 2002 to Oct 2007 were analysed and studied retrospectively. Result A total of 679 strains of gscherichia coli were isolated . The checkout rates were 18.6% of G-bacteria. There was an elevated tendency of the resistance rates to common antibacterials in Escherichia coli during the past six years. There were imipenim, amikacin, piperacillin/tazobactam, which the average resistance rate is less than 30%. Except piperacillin/tazobactam, the other antibacterial drug resistance rate had changed remarkably. Conclusion gscherichia coli had an elevated tendency on resistance rates, and the phenomenon of multi-drug resistance was serious To prevent the Escherichia coli infection outbreak, it is very important to advocate the reasonable medication and control the use of broad-spectrum antibiotic and carry out the drug sensitive trial of bacteria before beginning treatment of a infection by Escherichia coll.