雌激素受体在支气管哮喘患者肥大细胞上的表达及其意义

The expression of Estrogen Receptors in Mucosal Mast Cells in Bronchial Asthma Patients and its Clinical Significance

目的:研究雌激素受体在支气管哮喘患者支气管粘膜肥大细胞中的表达及意义。方法:采用抗人肥大细胞类胰酶单克隆抗体、抗人雌激素单克隆抗体对12例支气管哮喘患者支气管粘膜标本进行免疫组化及双标免疫染色。结果:雌激素受体阳性细胞与肥大细胞相似、位置相吻合。结论:支气管哮喘患者的支气管粘膜中肥大细胞表达雌激素受体,提示雌激素参与呼吸道变态反应以及炎性疾病。

Objective To explore the expression of estrogen receptors in mucosal mast cells in bronchial asthma patients and its clinical significance. Methods With monoclonal antibodies against human mast cell pancreatin and human estrogen receptors, immunohistochemical and dual immunostaining methods were used to detect and locate mast ceils from 12 cases of bronchial asthma mucosal specimens, Results The estrogen receptor positive ceils were coincided highly with mast cells in morphology and location. Conclusion The expression of estrogen receptors in mucosal mast cells in bronchial asthma patients indicates that estrogen may involve in respiratory allergy and inflammatory diseases.