2型糖尿病肾病患者血清胱抑素C的检测意义

Detection of Serum Cystatin C in Type 2 Diabetic Nephropathy Patients and Its Clinical Significance

目的:探讨2型糖尿病患者血液中胱抑素C(CysC)的变化与各种并发症的关系。方法:采用乳胶颗粒增强免疫比浊法测定28例2型糖尿病肾病患者血清胱抑素C,同时测定血尿素(Urea)、肌酐(Cr)及肌酐清除率(CCr),比较CysC与CCr、Cr的相关性及ROC曲线下面积。并与76例糖尿病非肾病患者和46例健康体检者比较。结果:2型糖尿病伴肾病组血清CysC和Cr均显著高于单纯性糖尿病组及血管并发症组和感染组,CysC和CCr两者呈负相关,CysC对糖尿病肾病诊断的ROC曲线下面积比Cr要大。结论:CysC可作为反映肾功能早期损害的指标,对2型糖尿病肾病有较高的诊断价值。

Objective To investigate the relationship between the content of serum cystatin C and complication of type 2 diabetic mellitus. Methods Twenty eight patients of diabetic nephropathy,76 diabetic mellitus without renal dysfunction and 46 healthy volunteers were enrolled. The serum levels of cystatin C（ Cys C） were determined by particle - enhanced immunoturbidimetry. Urea,Cr and CCr were also determined. Then the correlation of Cys C with Cr and CCr was compared, the area under ROC curve was calculated, respectively. Results Cys C and Cr were significantly higher in diabetic nephropathy patients than the other patients. Cys C was negatively correlated with Ccr, the Cys C was superior than Cr in diagnosing diabetic nephropathy. Conclusion Cys C can be a reliable indicator for early impairment of renal function ,and will be helpful for diagnosis of type 2 diabetic nephropathies.