原发性干燥综合征患者抗环瓜氨酸肽抗体检测

Examination of anti-cyclic citrullinated peptide antibodies in patients with primary Sjogren's syndrome

目的调查原发性干燥综合征患者抗环瓜氨酸肽[anti-cyclic citrullinated peptide（anti—CCP），抗CCP]抗体阳性率。方法134例原发性干燥综合征患者入选，符合2002年修订的干燥综合征国际分类标准。抗CCP抗体和类风湿因子（RF）分别采用酶联免疫吸附试验（ELISA）和散射速率比浊法测定。结果134例原发性干燥综合征患者，病程（11．1±6.6）年。80例类风湿因子（RF）阳性（59．7%），10例抗CCP抗体阳性，阳性率为7．46%（3．01％～11．91％）。抗CCP抗体阳性和抗CCP抗体阴性患者在临床和实验室指标方面差异无显著性。结论大多数原发性干燥综合征患者抗CCP抗体阴性，但是阳性检测结果不能排除原发性干燥综合征的诊断。抗CCP抗体阳性患者有可能发展为类风湿关节炎，需要密切的临床和放射学随访。

Objectives To investigate the prevalence of anti-cyclic eitrullinated peptide （anti-CCP） antibodies in patients with primary Sjogren＇s syndrome Methods 134 patients with primary Sjogren＇s syndrome were recruited. Anti-CCP antibody and rheumatoid factor （RF） were evaluated with enzyme linked immunosorbent assay kits and standard nephelometry methods, respectively. Results Of 134 patients, 80 eases（59%） were positive for rheumatoid factor （RF） and 10 cases （7.5 %） for anti-CCP. There was no difference in clinical and biological features between anti- CCP positive and negative patients. Conclusions Most patients with primary Sjogren＇s syndrome are negative in anti- CCP, but patients with positive results should not be rule out diagnosis for primary Sjogren＇s syndrome.