血液灌流治疗急性毒鼠强中毒35例临床分析

Clinical analysis of 35 patients with acute tetramine poisoning treated with hemoperfusion

目的观察血液灌流联合内科处理治疗急性毒鼠强中毒的临床疗效。方法对35例急性毒鼠强中毒患者除给予内科常规治疗外,同时进行血液灌流治疗,灌流时肝素首剂量1.0～1.5mg/kg,以后每半小时追加肝素4～8mg,血流量保持在每分种180～200ml,透析液流量500ml/min,一次灌流2小时,每日可灌流2次,连续灌流2～3d。结果27例重症患者连续灌流2日,每日4小时后清醒,8例轻症患者灌流2～4h后症状明显改善,未再抽搐,35例患者均治愈出院。结论血液灌流能有效清除血浆中的毒鼠强,对治疗急性毒鼠强中毒患者具有重要的临床应用价值。

Objective Clinical observation of hemoperfusion combined with internal medical treatment of patients with acute tetramine poisoning. Methods 35 patients with acute tetramine poisoning were treated with hemoperfusion besides conventional medical treatment. Results 27 severe patients were awake after continuous perfusion for two days. 8 mild patients recovered after a hemoperfusion. All of the 35 patients were healing. Conclusion Effective hemoperfusion can cure patients with acute tetramine poisoning.