饮酒对成人红细胞免疫及其调节功能影响的研究

Influence of drink on the immunity of erythrocytes in adult and its regulation

目的探讨饮酒对红细胞免疫及其调节功能的影响。方法对饮酒组(94人)和对照组(62人)健康成人分别检测其红细胞受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)、红细胞免疫增强因子(EF)及抑制因子(IF)的变化。结果饮酒组的RBC-C3bRR、EF水平低于非饮酒组(P均<0.01),而RBC-ICR水平则高于非饮酒对照组(P<0.01);相关分析表明RBC-C3bRR、EF水平与饮酒量及饮酒时间负相关,而RBC-ICR、IF水平则与被动饮酒量及饮酒时间呈正相关。结论长期大量饮酒可引起继发性免疫功能低下及降低红细胞免疫调节能力。

Objective To explore the impacts of drink on immunity of Erythrocytes in adult and its regulation. Methods Four indexes were determined：the forming rates of red blood cell C3b receptor rosette （RBC-C3bRR） ,red blood cell inunune complex rosette （RBC-ICR） ,the enhancing activities of factor （EF） and inhibitory factor （IF） of erythrocytes. Drinker group （94 cases, healthy adult ） and non-drinker control group （62 cases, healthy adult） were observed. Results Significant lower forming rate of RBC-C3bRR and activity of EF,siguificant higher forming rate of RBC-ICR were found in drinker group as compared with non-drinker group （ P 〈 0. 01 ）. Furthermore,the correlative analysis showed that the forming rate of RBC-C3bRR and the EF activity had a significant negative correlation with the amount and duration of drinking,howevr,the forming rates of RBC-lCR and EF activity had a significant positive correlation with the amount and duration of drinking. Conclusion Drinking had a secondary deterioration on the immunity and its regulation function.