武汉地区戊型肝炎流行病学特点调查

Epidemiology of hepatitis E in Wuhan region

目的调查武汉地区普通人群戊型肝炎病毒（HEV）感染的流行病学特点。方法2006年1—12月来武汉科技大学附属汉阳医院常规体检人员进行整群抽样并抽血，应用ELISA方法检测血清中戊型肝炎病毒（HEV）IgG水平，同时检测体检人员血清ALT水平，用统计学方法分析本地区普通人群HEV感染情况及特点。结果常规体检的3561人员中HEV总感染率为30．50％，HEV-IgG阳性率男性为37．92％，女性为23．31％；20岁以下人群阳性率〈1％，男性比女性感染率高，感染率随年龄上升而上升。HEV—IgG阳性人群ALT水平与HEV-IgG阴性人群无显著性差异。结论武汉地区男性和年长人群具有较高的HEV感染风险，20岁以下人群中HEV—IgG阳性率极低，学校等地方戊肝暴发的预防应引起高度重视。

Objective To investigate the epidemic status of hepatitis E virus （HEV）infection in Wuhan region. Methods Blood samples were detected for those who came for routine physical examination, hepatitis E virus IgG and level of ALT in serum were detected by ELISA. Statistical method was applied to analyze all the data. Results Among the 3 561 individuals,30. 50% had HEV infection, 37.92% were HEV-IgC positive in male,23.31% were positive in female; less than 1% were HEV-IgG positive in the group below 20 years old;The rate of infection in male was higher than that in female,the rate of infection increased with the age,but the level of ALT in those not being infected by HEV was not related with infection. Conclusion Males and people of higher age were more risky in HEV infection, HEV-IgG infection rate in people below 20 years old was less than 1%. More attention should be paid to prevent the outbreak of HEV in schools.